Structure of PDB 7q4p Chain B Binding Site BS01

Receptor Information
>7q4p Chain B (length=117) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFK
RKYLQGKRGIEKPPFELPDFIKRTGIQDYQKLHDAFFKWQTKPKLTIHGD
LYYEGKEFDRTPWGELE
Ligand information
>7q4p Chain 2 (length=45) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucggccgcuaagauuaguaucuguucuuaucaguuuaauaucuga
..<<<.<<<<....>>>>....>>>....<<<<........>>>>
Receptor-Ligand Complex Structure
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PDB7q4p Structural basis of branch site recognition by the human spliceosome.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		R459 T481 W504 K507 R508
Binding residue
(residue number reindexed from 1)		R2 T24 W47 K50 R51
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7q4p, PDBe:7q4p, PDBj:7q4p
PDBsum7q4p
PubMed34822310
UniProtQ13435|SF3B2_HUMAN Splicing factor 3B subunit 2 (Gene Name=SF3B2)

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