Structure of PDB 7q2x Chain B Binding Site BS01

Receptor Information

>7q2x Chain B (length=388) Species: 559292 (Saccharomyces cerevisiae S288C)

QLSPVKNSRVELQKIYDRHQSRLFINELVLENFKSYAGKQVVGPFHTSFS
AVVGPNGSGKSNVIDSMLFVFGFRANKMRQDRLSDLIHKSEAFPSLQSCS
VAVHFQYVIDESSGTSRIDEEKPGLIITRKAFKNNSSKYYINEKESSYTE
VTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYLEDII
GTANYKPLIEERMGQIENLVQKRDEVKEQLGILKKKRFDEFMAGFNIISM
TLKEMYQMITMGGNAELELVDSLDPFSEGVTFSVMPPKKSWRNITNLSGG
EKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNA
QFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKNIDI

Ligand information

>7q2x Chain G (length=36)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 7q2x Clamping of DNA shuts the condensin neck gate.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): R205 L214 S268 S278
• Binding residue (residue number reindexed from 1): R74 L83 S137 S147

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0000070 mitotic sister chromatid segregation
• GO:0007059 chromosome segregation
• GO:0007076 mitotic chromosome condensation
• GO:0030261 chromosome condensation
• GO:0051276 chromosome organization
• GO:0051301 cell division
• GO:0070058 tRNA gene clustering
• GO:0070550 rDNA chromatin condensation

Cellular Component

• GO:0000796 condensin complex
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7q2x, PDBe:7q2x, PDBj:7q2x
• PDBsum: 7q2x
• PubMed: 35349345
• UniProt: Q12267|SMC4_YEAST Structural maintenance of chromosomes protein 4 (Gene Name=SMC4)