Structure of PDB 7plo Chain B Binding Site BS01

Receptor Information
>7plo Chain B (length=759) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELGV
YETQVPLLFVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRH
IYLYHHAQAVFVLDTVRSLYSAEHGLLLEKVPPPKHTFEVRAETDLKTLA
YKEERRGPTLIAVQSSWELKRLASEIPFPLVPICVNYGVLDWQRHGARRM
IRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTHNHLLWLSPTARPDLG
GKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHV
NDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRIL
KSMPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVE
DAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSS
RIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVQFLPQAASC
QNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVITFSQDYVANELTQSFF
TITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSL
DTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFC
RDLDLCKDSVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVC
LKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLL
ETLEWLLQK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7plo Chain B Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C2221 C2224 C2236
Binding residue
(residue number reindexed from 1)		C700 C703 C715
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0045004 DNA replication proofreading
GO:0048568 embryonic organ development
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0008622 epsilon DNA polymerase complex
GO:0031981 nuclear lumen

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtQ07864|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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