Structure of PDB 7pgc Chain B Binding Site BS01

Receptor Information

>7pgc Chain B (length=155) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKR

Ligand information

>7pgc Chain C (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KPcKK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7pgc Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Resolution	1.55 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161
Binding residue (residue number reindexed from 1)	H36 D114 Y115 A117 S120 G136 N137 G138 V140 Y146

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7pgc, PDBe:7pgc, PDBj:7pgc
PDBsum	7pgc
PubMed	35475620
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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