Structure of PDB 7pg1 Chain B Binding Site BS01

Receptor Information

>7pg1 Chain B (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKR

Ligand information

>7pg1 Chain D (length=6) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KGAGKK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7pg1 Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Resolution	1.95 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 A132 S135 G151 N152 G153 Y161
Binding residue (residue number reindexed from 1)	H35 D113 Y114 A116 S119 G135 N136 G137 Y145

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7pg1, PDBe:7pg1, PDBj:7pg1
PDBsum	7pg1
PubMed	35475620
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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