Structure of PDB 7pfz Chain B Binding Site BS01

Receptor Information
>7pfz Chain B (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pfz Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Resolution1.45 Å
Binding residue
(original residue number in PDB)
H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161
Binding residue
(residue number reindexed from 1)
H35 D113 Y114 A116 S119 G135 N136 G137 V139 Y145
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7pfz, PDBe:7pfz, PDBj:7pfz
PDBsum7pfz
PubMed35475620
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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