Structure of PDB 7pfz Chain B Binding Site BS01
Receptor Information
>7pfz Chain B (length=154) Species:
64320
(Zika virus) [
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ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKR
Ligand information
>7pfz Chain C (length=5) Species:
32630
(synthetic construct) [
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KKKcA
Receptor-Ligand Complex Structure
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PDB
7pfz
Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Resolution
1.45 Å
Binding residue
(original residue number in PDB)
H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161
Binding residue
(residue number reindexed from 1)
H35 D113 Y114 A116 S119 G135 N136 G137 V139 Y145
Enzymatic activity
Enzyme Commision number
2.1.1.56
: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57
: methyltransferase cap1.
2.7.7.48
: RNA-directed RNA polymerase.
3.4.21.91
: flavivirin.
3.6.1.15
: nucleoside-triphosphate phosphatase.
3.6.4.13
: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0003724
RNA helicase activity
GO:0005524
ATP binding
View graph for
Molecular Function
External links
PDB
RCSB:7pfz
,
PDBe:7pfz
,
PDBj:7pfz
PDBsum
7pfz
PubMed
35475620
UniProt
Q32ZE1
|POLG_ZIKV Genome polyprotein
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