Structure of PDB 7p9u Chain B Binding Site BS01

Receptor Information
>7p9u Chain B (length=455) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGA
LSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISL
AFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFL
TFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMY
AYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINA
EELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYV
ASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSF
ARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLY
SDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEV
VPEED
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain7p9u Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7p9u Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R135 A138 I142 Y244 A247 F250 Y251
Binding residue
(residue number reindexed from 1)		R91 A94 I98 Y200 A203 F206 Y207
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015327 cystine:glutamate antiporter activity
GO:0022857 transmembrane transporter activity
GO:0140926 L-kynurenine transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006749 glutathione metabolic process
GO:0006865 amino acid transport
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0008542 visual learning
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0015804 neutral amino acid transport
GO:0015811 L-cystine transport
GO:0015813 L-glutamate transmembrane transport
GO:0021591 ventricular system development
GO:0021756 striatum development
GO:0030534 adult behavior
GO:0033029 regulation of neutrophil apoptotic process
GO:0033554 cellular response to stress
GO:0034599 cellular response to oxidative stress
GO:0034775 glutathione transmembrane transport
GO:0035094 response to nicotine
GO:0042127 regulation of cell population proliferation
GO:0048021 regulation of melanin biosynthetic process
GO:0048286 lung alveolus development
GO:0050804 modulation of chemical synaptic transmission
GO:0050807 regulation of synapse organization
GO:0051223 regulation of protein transport
GO:0051775 response to redox state
GO:0055085 transmembrane transport
GO:0060173 limb development
GO:0070306 lens fiber cell differentiation
GO:0070527 platelet aggregation
GO:0090461 intracellular glutamate homeostasis
GO:0098712 L-glutamate import across plasma membrane
GO:0110076 negative regulation of ferroptosis
GO:0140206 dipeptide import across plasma membrane
GO:0140924 L-kynurenine transmembrane transport
GO:1900407 regulation of cellular response to oxidative stress
GO:1901494 regulation of cysteine metabolic process
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903786 regulation of glutathione biosynthetic process
GO:1904717 regulation of AMPA glutamate receptor clustering
GO:2000211 regulation of glutamate metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0042995 cell projection
GO:0045177 apical part of cell
GO:0097449 astrocyte projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p9u, PDBe:7p9u, PDBj:7p9u
PDBsum7p9u
PubMed34880232
UniProtQ9UPY5|XCT_HUMAN Cystine/glutamate transporter (Gene Name=SLC7A11)

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