Structure of PDB 7p3t Chain B Binding Site BS01

Receptor Information
>7p3t Chain B (length=299) Species: 565045 (Luminiphilus syltensis NOR5-1B) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDEPIIYINGDYLPLSQARVSPVDQGFLLGDGVFDVVSAWKGNIFKLDAH
LDRFFDSIQAARLNHDMSRDAWKEAIIETTRRNGLDDASIRFIVTRGEPK
GVVADPRDFKPTCIVWVAPYIFLADEEKRRNGIRLMISATRGFPADTLDP
RYKCLDRLHSQLIRLEALEAGYDDALWLDHSGHVSESAASNLFIVKNGVL
YTPSAGILRGITRDTILELATELDIPWKERQLSAFDVYIADEVFTCSTAG
GALPVREVAGRTIRGTTPGPITQAIDNAYWAMRETDRYATPLSGSHHHH
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain7p3t Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7p3t Rational engineering of Luminiphilus syltensis ( R )-selective amine transaminase for the acceptance of bulky substrates.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		R54 K154 R158 E187 S188 A189 A190 S191 G211 I212 T213 T249
Binding residue
(residue number reindexed from 1)		R53 K153 R157 E186 S187 A188 A189 S190 G210 I211 T212 T248
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:0046394 carboxylic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7p3t, PDBe:7p3t, PDBj:7p3t
PDBsum7p3t
PubMed34806715
UniProtB8KQT8

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