Structure of PDB 7oqy Chain B Binding Site BS01

Receptor Information
>7oqy Chain B (length=1105) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLDTESRWAIAESFFKTRGLVRQHLDSFNDFLRNKLQQVIYEQGEIVTEV
PGLKIKLGKIRYEKPSIRETDKGPMREITPMEARLRNLTYSSPIFLSMIP
VENNIEGEPIEIYIGDLPIMLKSVADPTSNLPIDKLIEIGEDPKDPGGYF
IVNGSEKVIIAQEDLATNRVLVDYGKSGSNITHVAKVTSSAAGYRVQVMI
ERLKDSTIQISFATVPGRIPFAIIMRALGFVTDRDIVYAVSLDPQIQNEL
LPSLEQASSITSAEEALDFIGNRVAIGQKRENRIQKAEQVIDKYFLPHLG
TSPEDRKKKGYYLASAVNKILELYLGRREPDDKDHYANKRVRLAGDLFTS
LFRVAFKAFVKDLVYQLEKSKVRGRRLSLTALVRADIITERIRHALATGN
WVGGRTGVSQLLDRTNWLSMLSHLRRVVSSLAPNFEARDLHGTQWGRMCP
FETPEGPNSGLVKNLALLAQVSVGINESVVERVAYELGVVSVEDVIRRIS
EQNEDVEKYMSWSKVYLNGRLLGYYEDGKELAKKIRESRRQGKLSDEVNV
AYIATDYLNEVHINCDAGRVRRPLIIVNNGTPLVDTEDIKKLKNGEITFD
DLVKQGKIEFIDAEEEENAYVALNPQDLTPDHTHLEIWPSAILGIIASII
PYPEHNQSPRNTYQSAMAKQSLGLYASNYQIRTDTRAHLLHYPQMPLVQT
RMLGVIGYNDRPAGANAILAIMSYTGYNMEDSIIMNKSSIERGMYRSTFF
RLYSTEEVKYPGGQEDKIITPEAGVKGYKGKDYYRLLEDNGVVSPEVEVK
GGDVLIGKVSPPRAKRDTSIVTRHGENGIVDLVLITETLEGNKLVKVRVR
DLRIPEIGDKFATRHGQKGVVGILIDQVDMPYTAKGIVPDIILNPHALPS
RMTIGQIMEAIGGKYAALSGKPVDATPFLETPKLQEMQKEILKLGHLPDS
TEVVYDGRTGQKLKSRILFGIVYYQKLHHMVADKMHARARGPVQILTRQP
TEGRAREGGLRFGEMERDCLIGFGTAMLIKDRLLDNSDKAVVYICDQCGY
VGWYDRSKNRYVCPVHGDKSVLHPVTVSYAFKLLIQELMSMVISPRLILG
EKVNL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7oqy Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7oqy Structural basis of RNA polymerase inhibition by viral and host factors.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		C1060 H1081
Binding residue
(residue number reindexed from 1)		C1045 H1066
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oqy, PDBe:7oqy, PDBj:7oqy
PDBsum7oqy
PubMed34535646
UniProtP11513|RPO2_SULAC DNA-directed RNA polymerase subunit Rpo2 (Gene Name=rpo2)

[Back to BioLiP]