Structure of PDB 7ogj Chain B Binding Site BS01

Receptor Information
>7ogj Chain B (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKPEEMDWSELYPEFFAPLTQAQAQVEFADIGCGYGGLLVELSPLFPDTL
ILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKG
QLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLE
LHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNF
PAIFRRIQDPVL
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain7ogj Chain B Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ogj Crystal structure of human METTL1 in complex with SAH
Resolution1.59 Å
Binding residue
(original residue number in PDB)		G54 C55 G56 E77 I78 R79 S109 N110 A111 L130 F131 D133 H135 T208 E210
Binding residue
(residue number reindexed from 1)		G32 C33 G34 E55 I56 R57 S87 N88 A89 L108 F109 D111 H113 T186 E188
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase.
Gene Ontology
Molecular Function
GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ogj, PDBe:7ogj, PDBj:7ogj
PDBsum7ogj
PubMed
UniProtQ9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Gene Name=METTL1)

[Back to BioLiP]