Structure of PDB 7ob9 Chain B Binding Site BS01

Receptor Information
>7ob9 Chain B (length=1129) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAV
HEGLGLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYP
AECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRN
LPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKT
RGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLG
FALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMT
RKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAF
DKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQD
SGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPV
HTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSY
SECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDE
VFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPL
LTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTG
YDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGD
PRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVD
NIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPF
IFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQ
RLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGT
SFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPRNRKYNCTLCSRSDT
IDTVSVPYVFRYFVAELAAMNIKVKLDVV
Ligand information
>7ob9 Chain R (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaugcgcauaacgccacagag
<<<<..>>>>...........
Receptor-Ligand Complex Structure
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PDB7ob9 Cryo-EM structures of human RNA polymerase I.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R180 K882 K890 H1004 G1016 A1017 R1020
Binding residue
(residue number reindexed from 1)		R180 K882 K890 H1004 G1016 A1017 R1020
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0007566 embryo implantation
GO:0009303 rRNA transcription
GO:0014029 neural crest formation
GO:0017126 nucleologenesis
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ob9, PDBe:7ob9, PDBj:7ob9
PDBsum7ob9
PubMed34887565
UniProtQ9H9Y6|RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (Gene Name=POLR1B)

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