Structure of PDB 7o55 Chain B Binding Site BS01

Receptor Information

>7o55 Chain B (length=154) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDP
YWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFK
TKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQ
GKRE

Ligand information

>7o55 Chain C (length=6) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KKKGAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7o55 Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
Resolution	1.95 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 A132 S135 G151 N152 G153 Y161
Binding residue (residue number reindexed from 1)	H34 D112 Y113 A115 S118 G134 N135 G136 Y144

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7o55, PDBe:7o55, PDBj:7o55
PDBsum	7o55
PubMed	35475620
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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