Structure of PDB 7nis Chain B Binding Site BS01

Receptor Information
>7nis Chain B (length=735) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFKKKQRLNKRSYLIRA
LTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGL
PVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAM
ITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAE
MLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGV
SILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCK
LLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESA
DMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTR
RSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQ
GRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIPKRN
RSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSR
ARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7nis Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Resolution5.96 Å
Binding residue
(original residue number in PDB)		N671 S673 I674 N676
Binding residue
(residue number reindexed from 1)		N650 S652 I653 N655
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nis, PDBe:7nis, PDBj:7nis
PDBsum7nis
PubMed35017564
UniProtQ3HM40|RDRP_I18A0 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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