Structure of PDB 7nh7 Chain B Binding Site BS01

Receptor Information
>7nh7 Chain B (length=120) Species: 31631 (Human coronavirus OC43) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPD
ATTSQDSYGGASVCIYCRARVEHPDVDGLCKLRGKFVQVPVGIKDPVSYV
LTHDVCRVCGFWRDGSCSCV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7nh7 Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nh7 OC43 coronavirus methyltransferase
Resolution2.2 Å
Binding residue
(original residue number in PDB)		C116 C119 C127 C129
Binding residue
(residue number reindexed from 1)		C106 C109 C117 C119
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7nh7, PDBe:7nh7, PDBj:7nh7
PDBsum7nh7
PubMed
UniProtP0C6U7|R1A_CVHOC Replicase polyprotein 1a (Gene Name=1a)

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