Structure of PDB 7n94 Chain B Binding Site BS01

Receptor Information

>7n94 Chain B (length=232) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKI
KGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQ
EELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGAFNTPLSTLDRS
TRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKIDH
IVGSKALLSKCKRTEIITNKLSDHSAIKLELR

Ligand information

>7n94 Chain D (length=18) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gctcctttttaagggcta

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7n94 Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	R60 I62 Y63 R91
Binding residue (residue number reindexed from 1)	R54 I56 Y57 R85

Enzymatic activity

Enzyme Commision number

2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

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Molecular Function

External links

PDB	RCSB:7n94, PDBe:7n94, PDBj:7n94
PDBsum	7n94
PubMed	34554261
UniProt	O00370\|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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