Structure of PDB 7myv Chain B Binding Site BS01

Receptor Information

>7myv Chain B (length=239) Species: 36329 (Plasmodium falciparum 3D7)

KAIFLFDVDGTLTISRKTIEQNVVDTLLELKSKKGFVLGIVGGSDYKKIR
EQIKYPEIFDYIFSENGVVAHKNDEEYFAESIVNFLGEDRLKKLINYSLK
YIANLDIPKKRGTFIELRNGIINISPIGRNCSQEERDEFFRYNLKNNTIE
KFRDNLSKEFEDFDLNFSMGGQISIDCFPKGWDKTFCLKHLENKFDEIYF
FGDRTDKGGNDYELFCDKRVKGYKVKNPNDTVKILRENF

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7myv Chain B Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7myv Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites.
• Resolution: 3.51 Å
• Binding residue (original residue number in PDB): D14 D16 D210
• Binding residue (residue number reindexed from 1): D7 D9 D203
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.4.2.8: phosphomannomutase.

Gene Ontology

Molecular Function

• GO:0004615 phosphomannomutase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006013 mannose metabolic process
• GO:0006487 protein N-linked glycosylation
• GO:0009298 GDP-mannose biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7myv, PDBe:7myv, PDBj:7myv
• PDBsum: 7myv
• PubMed: 34973333
• UniProt: Q8IJM5