Structure of PDB 7mvs Chain B Binding Site BS01

Receptor Information
>7mvs Chain B (length=675) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANSRINERNIT
SEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYK
KSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDG
DGAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFP
NLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEG
PDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIP
FQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANAS
VILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRR
RTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRF
KLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVL
LQLVRDELTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
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PDB7mvs Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Resolution2.60137 Å
Binding residue
(original residue number in PDB)		K53 I54 L55 N56 K59 R64 H108 R188 R323 F324 I376 G379 M380 R439
Binding residue
(residue number reindexed from 1)		K44 I45 L46 N47 K50 R55 H99 R179 R307 F308 I360 G363 M364 R423
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7mvs, PDBe:7mvs, PDBj:7mvs
PDBsum7mvs
PubMed34614347
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB);
P20831

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