Structure of PDB 7mso Chain B Binding Site BS01
Receptor Information
>7mso Chain B (length=221) Species:
9606
(Homo sapiens) [
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HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANITPEGDELARLPYLRTWFRTRSAIIL
HLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCC
KELASRLRYARTMVDKLLSSR
Ligand information
>7mso Chain F (length=5) Species:
32630
(synthetic construct) [
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QSTPL
Receptor-Ligand Complex Structure
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PDB
7mso
Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
W414 V415 D416 Y485 E488 H489 L490 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)
W42 V43 D44 Y113 E116 H117 L118 L119 R143 H165 K167
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:7mso
,
PDBe:7mso
,
PDBj:7mso
PDBsum
7mso
PubMed
35029981
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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