Structure of PDB 7mid Chain B Binding Site BS01

Receptor Information
>7mid Chain B (length=340) Species: 243231 (Geobacter sulfurreducens PCA) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRGLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARLGETSQVALFGNATL
TTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPE
TCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAM
RAPSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMGFDFTTRNRRPPKDP
VNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPF
RPLIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQ
EVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mid Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		P229 K230 Y232 E243 R246 N265
Binding residue
(residue number reindexed from 1)		P11 K12 Y14 E25 R28 N47
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.1.12.1: 5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:7mid, PDBe:7mid, PDBj:7mid
PDBsum7mid
PubMed34588691
UniProtQ74H36|CS4F1_GEOSL CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion (Gene Name=cas4-cas1)

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