Structure of PDB 7lv3 Chain B Binding Site BS01

Receptor Information
>7lv3 Chain B (length=594) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKRQAISAEPTDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQ
EIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPG
KVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYM
EFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISK
GTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTC
LVIDRDSFKHLIGAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELV
QLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRT
FKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHS
KGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAP
EIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI
EFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL
RKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7lv3 Chain B Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lv3 An auto-inhibited state of protein kinase G and implications for selective activation.
Resolution2.41 Å
Binding residue
(original residue number in PDB)		N504 D517
Binding residue
(residue number reindexed from 1)		N412 D425
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7lv3, PDBe:7lv3, PDBj:7lv3
PDBsum7lv3
PubMed35929723
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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