Structure of PDB 7luf Chain B Binding Site BS01

Receptor Information
>7luf Chain B (length=1054) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFYNPYLAPVGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHL
KRAPKVYCGGDERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHV
YDILENVEHAYGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVY
GTRQYFYMNKEEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFE
AEVVERTDVYYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDA
TTRFILDNPGFVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADN
LAIEGGMSDLPAYKLMCFDIACKAGGEDELAFPVAGHPEDLVIQISCLLY
DLSTTALEHVLLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLA
FMTLVKQYGPEFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVF
RVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLK
DKKKDLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELS
AVARLAGINITRTIYDGQQIRVFTCLLRLADQKGFILPDTQRHVGYQGAR
VHDPTSGFHVNPVVGFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGK
DYLEIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEA
VLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATRE
YVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAA
GLTAMGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKM
LIKGVDLVRKNNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLA
RPLPEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLA
HLTVYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALREVSELA
EDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIP
EVWH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7luf Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		F509 Q510 K514 G616 Q617 Q618 Q640 G695 Y696 Q697 G698 V701 L827 K938 K939 K940 R959 R1048 V1139 S1140 Y1160 H1164
Binding residue
(residue number reindexed from 1)		F460 Q461 K465 G567 Q568 Q569 Q591 G595 Y596 Q597 G598 V601 L727 K838 K839 K840 R859 R948 V996 S997 Y1017 H1021
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0042025 host cell nucleus
GO:0042575 DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7luf, PDBe:7luf, PDBj:7luf
PDBsum7luf
PubMed34031403
UniProtP04293|DPOL_HHV11 DNA polymerase catalytic subunit (Gene Name=UL30)

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