Structure of PDB 7lt5 Chain B Binding Site BS01

Receptor Information
>7lt5 Chain B (length=576) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDII
KNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNI
HRHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSL
KKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFY
KKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGAN
IFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSK
FEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITG
CDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDID
NENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKI
MYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSV
YDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILL
NKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lt5 Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Resolution2.54 Å
Binding residue
(original residue number in PDB)
K25 G28 Y30 N165 Y168 H171 K193 Y221 S227 F253 I256 G257 Q346 R432 W439 R441 K456 Y476 K511 M513 Y521 P522 N523
Binding residue
(residue number reindexed from 1)
K24 G27 Y29 N164 Y167 H170 K192 Y220 S226 F252 I255 G256 Q345 R431 W438 R440 K455 Y475 K510 M512 Y520 P521 N522
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:7lt5, PDBe:7lt5, PDBj:7lt5
PDBsum7lt5
PubMed34103525
UniProtQ183J3

[Back to BioLiP]