Structure of PDB 7lps Chain B Binding Site BS01
Receptor Information
>7lps Chain B (length=381) Species:
9606
(Homo sapiens) [
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INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQT
LPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYRE
EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSA
VQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMD
RIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGY
VHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTAT
KKDMSPQKFWGLTRSALLPTIPDTEDEISPD
Ligand information
>7lps Chain C (length=29) Species:
9606
(Homo sapiens) [
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GERPFHCNQCGASFTQKGNLLRHIKLHSG
Receptor-Ligand Complex Structure
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PDB
7lps
Acute pharmacological degradation of Helios destabilizes regulatory T cells.
Resolution
3.78 Å
Binding residue
(original residue number in PDB)
N351 H353 Y355 W386 V388 Q390 A395 H397
Binding residue
(residue number reindexed from 1)
N296 H298 Y300 W331 V333 Q335 A340 H342
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7lps
,
PDBe:7lps
,
PDBj:7lps
PDBsum
7lps
PubMed
34035522
UniProt
Q96SW2
|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)
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