Structure of PDB 7lhz Chain B Binding Site BS01

Receptor Information
>7lhz Chain B (length=631) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNT
WEVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLH
IATLLCALFVRHFRTLVKEGHVYVALPPLYQRFKGLGEMNPMQLRETTLD
PNTRRLVQLVISDEDEQQTTAIMDMLLAKKRSEDRRNWLQEKGSDMAERL
ALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASA
KFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGA
PDDPKSFAAMRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLP
ARLPNILLNGTTGIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLD
IVQGPDFPTEAEIITSRAEIRKIYQNGRGSVRMRAVLPHQVSGAKVLEQI
AAQMRNEQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLV
FRRDTVRRRLNHRLEKVLKRLHILEGLLVAFLNIDEVIEIIRTEDEPKPA
LMSRFGISETQAEAILELKLRHLAKLEEMKIRGEQSELEKERDQLQAILA
SERKMNNLLKKELQADADAFGDDRRSPLHER
Ligand information
Receptor-Ligand Complex Structure
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PDB7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		E419 G443 K444 D495 R1029 V1041 Q1042 H1075 H1077 G1078 A1085 T1170 I1172
Binding residue
(residue number reindexed from 1)		E21 G45 K46 D97 R221 V233 Q234 H267 H269 G270 A277 T362 I364
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
PDBsum7lhz
PubMed33929852
UniProtB5XU53;
B5XU60

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