Structure of PDB 7l4i Chain B Binding Site BS01

Receptor Information
>7l4i Chain B (length=396) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPLRFPYGRPEFLGLSQDEVEASADHIARPILILKETRRLPWATGYAEVI
NAGKSTHNEDQASCEVLTVGVSCHYWSLFDGHAGSGAAVVASRLLQHHIT
EQLQDIVDILKFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISG
GCTALIVICLLGKLYVANAGASRAIIIRNGEIIPMSSEFTPETERQRLQY
LAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDED
LKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVR
IYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRY
TLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7l4i Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7l4i Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		D151 G152
Binding residue
(residue number reindexed from 1)		D80 G81
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7l4i, PDBe:7l4i, PDBj:7l4i
PDBsum7l4i
PubMed34580980
UniProtQ9ULR3|PPM1H_HUMAN Protein phosphatase 1H (Gene Name=PPM1H)

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