Structure of PDB 7l1k Chain B Binding Site BS01

Receptor Information
>7l1k Chain B (length=660) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGYVDCTKSYFEATKSLKEEQLVCDPKFTLLDSISAFEIMEPKMDSGIDY
QPLRVDFSRDLSYLEILALMDLIVSAEKEWHYGSPLSESLLCSAHVFSIC
KSGFSSGSGRNTTDIVLFPFVLAVIKCCDIVHREFLMGNLYDEEDISSFS
YHMSFLQNYPIEKLNYLLQSSIEYLASEVIKFSAELRQIIEGILNRIQLR
IGILRVYERSDIKTTIDALHLIKNLVPEIQNTVSVVDSSIKESILKQYWD
FRVQAQLVATAPVRNIPPTGIEHSYQRILYFADDMLLILNSHTLASSLAV
YQFCLDFTRLNRTPEPYVRSSLQALITANNAVNLRDQPTSYMLECIREFS
GLPSNFYNPNTRTVIEKNSISSAYGPLVESLIAHSTNIMVDLVRICSHNP
CRFRRNLINLLPEITVAHFEAEALDLKFSNGPFSSFIYHVKLNAIEHILL
SSFEQKLHQPYQWPHFFAVLDHVFSIHQTHLELHGKDRNTPPMAKTFVTY
LHRILNAIKETYSGYLLLTVLCMRLNIIKTPSFTLDEKIQESYYMAHYRP
LINLRQPKPLLRSEADCIIKNLQNFSTDDLIIKSNEKFTAAKNSLINVIK
SGFEQNEFINPYFLQTNYLKNLLCCCITNLVSLAILSKDHSANLKIVEIP
GNPLPSLSRT
Ligand information
Ligand IDIHP
InChIInChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24)/t1-,2-,3-,4+,5-,6-
InChIKeyIMQLKJBTEOYOSI-GPIVLXJGSA-N
SMILES
SoftwareSMILES
CACTVS 3.385O[P](O)(=O)O[CH]1[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH](O[P](O)(O)=O)[CH]1O[P](O)(O)=O
ACDLabs 12.01
OpenEye OEToolkits 2.0.7		C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O
CACTVS 3.385O[P](O)(=O)O[C@@H]1[C@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@@H](O[P](O)(O)=O)[C@H](O[P](O)(O)=O)[C@H]1O[P](O)(O)=O
FormulaC6 H18 O24 P6
NameINOSITOL HEXAKISPHOSPHATE;
MYO-INOSITOL HEXAKISPHOSPHATE;
INOSITOL 1,2,3,4,5,6-HEXAKISPHOSPHATE
ChEMBLCHEMBL1233511
DrugBankDB14981
ZINCZINC000169289809
PDB chain7l1k Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7l1k Molecular mechanism of N-terminal acetylation by the ternary NatC complex.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		R447 N451
Binding residue
(residue number reindexed from 1)		R405 N409
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
Biological Process
GO:0017196 N-terminal peptidyl-methionine acetylation
GO:0051604 protein maturation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031417 NatC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7l1k, PDBe:7l1k, PDBj:7l1k
PDBsum7l1k
PubMed34019809
UniProtQ9USY3|NAA35_SCHPO N-alpha-acetyltransferase 35, NatC auxiliary subunit (Gene Name=mak10)

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