Structure of PDB 7klz Chain B Binding Site BS01
Receptor Information
>7klz Chain B (length=139) Species:
9606
(Homo sapiens) [
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HMVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGL
DEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFV
QGKDWGFKKFIRRGFLLDEANGLLPDDKLTLFCEVSVVQ
Ligand information
>7klz Chain D (length=9) Species:
9606
(Homo sapiens) [
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EGTVSSSTD
Receptor-Ligand Complex Structure
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PDB
7klz
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Resolution
3.4 Å
Binding residue
(original residue number in PDB)
Y123 D130 W131 G132 F133
Binding residue
(residue number reindexed from 1)
Y97 D104 W105 G106 F107
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7klz
,
PDBe:7klz
,
PDBj:7klz
PDBsum
7klz
PubMed
34599168
UniProt
O43791
|SPOP_HUMAN Speckle-type POZ protein (Gene Name=SPOP)
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