Structure of PDB 7kfa Chain B Binding Site BS01

Receptor Information
>7kfa Chain B (length=471) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPWNLERITPPRYRSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEED
ASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLE
FIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFR
DDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDII
GASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFS
AKDVINEAWFPEDQRVLTPNLVAALPPSQLFCRTVWSAHSGPTRMATAIA
RCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAGEGVYAIARCC
LLPQANCSVHTAPPTRVHCHQQGHVLTGCSSHWEVEDQPNQCVGHEASIH
ASCCHAPGLECKVKEHGIQEQVTVACEEGWTLTGCSALPGTSHVLGAYAV
DNTCVVRSRAVTAVAICCRSR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7kfa Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		K222 S225 N317 F318 V346 L348 L351 G352 T353 E366 D367 Q382 S383 G384
Binding residue
(residue number reindexed from 1)		K53 S56 N148 F149 V177 L179 L182 G183 T184 E197 D198 Q213 S214 G215
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7kfa, PDBe:7kfa, PDBj:7kfa
PDBsum7kfa
PubMed34547225
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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