Structure of PDB 7kcl Chain B Binding Site BS01

Receptor Information
>7kcl Chain B (length=614) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISN
ASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELV
SNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYS
RSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVGEWQHEEFYRYVA
QAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRSSVALYSRKVLI
QTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRL
IKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYES
SALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDT
EVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHCLSEKETEELMAWM
RNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQTQEERAQLLQP
TLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMV
GRLNELLVKALERH
Ligand information
>7kcl Chain C (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VIKDLVPDLSNFYAQYKSIEPYL
Receptor-Ligand Complex Structure
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PDB7kcl Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates
Resolution3.14 Å
Binding residue
(original residue number in PDB)		M352 F353 H538 H620
Binding residue
(residue number reindexed from 1)		M283 F284 H466 H534
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019901 protein kinase binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009386 translational attenuation
GO:0060255 regulation of macromolecule metabolic process
GO:0061077 chaperone-mediated protein folding
GO:1901856 negative regulation of cellular respiration
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kcl, PDBe:7kcl, PDBj:7kcl
PDBsum7kcl
PubMed
UniProtQ12931|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (Gene Name=TRAP1)

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