Structure of PDB 7ka0 Chain B Binding Site BS01

Receptor Information
>7ka0 Chain B (length=835) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSNAMRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGPV
DGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLV
VVALPGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPG
AAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFVD
PASNSRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQR
RLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGET
AVTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAA
IWDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGG
EVSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQI
GAVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPA
GRGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRRM
TTRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQPT
EQTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWGP
GRPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSVG
HAGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDV
SLVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFAL
RFRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG
Ligand information
>7ka0 Chain C (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguagcucagucgguaugagcguccgccugaaaagcggaaggucggcgg
uucgaucccgccccug
<<<..<<<<<.......>>>>>.<<<<<.......>>>>>.....<<<<<
.......>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB7ka0 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Q744 D745 S747 D778 F780 Q784 T793 R830
Binding residue
(residue number reindexed from 1)		Q748 D749 S751 D782 F784 Q788 T797 R834
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ka0, PDBe:7ka0, PDBj:7ka0
PDBsum7ka0
PubMed33885823
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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