Structure of PDB 7k9m Chain B Binding Site BS01

Receptor Information
>7k9m Chain B (length=834) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSNAMRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGPV
DGPVTVGRVADIEELTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLV
VVALPGATLPGGFTISARKAYGRNSDGMICSAAELNLGADHSGILVLPPG
AAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVRGLARELACAYDLDFVD
PASNSRPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVSPWWLQRR
LLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGETA
VTLDGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAAI
WDPAAVSRTQRRLHLPSEAARRYERTVDPAISVAALDRCARLLADIAGGE
VSPTLTDWRGDPPCDDWSPPPIRMGVDVPDRIAGVAYPQGTTARRLAQIG
AVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLRLEGLEVIPSVLPPAPAG
RGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEADDSRRMT
TRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQPTE
QTRGVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWGPG
RPVEAADAFEAVRIIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSVGH
AGQLHPAVIERSGLPKGTCAVELNLDAIPCSAPLPAPRVSPYPAVFQDVS
LVVAADIPAQAVADAVRAGAGDLLEDIALFDVFTGPQIGEHRKSLTFALR
FRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG
Ligand information
>7k9m Chain C (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguagcucagucgguaugagcguccgccugaaaagcggaaggucggcgg
uucgaucccgccccug
<<<..<<<<<.......>>>>>.<<<<<.......>>>>>.....<<<<<
.......>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB7k9m Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q744 D745 S747 D778 F780 Q784 T793 R830
Binding residue
(residue number reindexed from 1)		Q747 D748 S750 D781 F783 Q787 T796 R833
Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall
GO:0009328 phenylalanine-tRNA ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k9m, PDBe:7k9m, PDBj:7k9m
PDBsum7k9m
PubMed33885823
UniProtP9WFU1|SYFB_MYCTU Phenylalanine--tRNA ligase beta subunit (Gene Name=pheT)

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