Structure of PDB 7k5k Chain B Binding Site BS01

Receptor Information
>7k5k Chain B (length=545) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLNS
APKHSSSGGSGGNGGSAGSSGNGEGGAQIKINSSVKDNTINEFLKEGNME
NFTGKLGTSKSFYIANDQKKYVSLAYVGCGPANEETELEIRKVAYALVTL
LHDSKHKKVSIIFEIKIEEALFRFFLEHLFYEYVTDERFKSADKSTETDF
IKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPVSLSNA
AVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLTYKGAQ
TGASQNEKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLG
CAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNT
DAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQ
LINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVA
SLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND
Ligand information
Ligand IDCO3
InChIInChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
InChIKeyBVKZGUZCCUSVTD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(=O)([O-])[O-]
ACDLabs 10.04
CACTVS 3.341		[O-]C([O-])=O
FormulaC O3
NameCARBONATE ION
ChEMBL
DrugBankDB14531
ZINC
PDB chain7k5k Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7k5k Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		A476 G478 R479 L503
Binding residue
(residue number reindexed from 1)		A402 G404 R405 L429
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7k5k, PDBe:7k5k, PDBj:7k5k
PDBsum7k5k
PubMed33303633
UniProtA5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)

[Back to BioLiP]