Structure of PDB 7jsk Chain B Binding Site BS01

Receptor Information
>7jsk Chain B (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLM
PVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALR
TLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQRKRL
CKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWF
AFAFPNMLVMLLFAWLWLQFVYMRSKKNEKAALKVLQEEYRKLGPLSFAE
INVLICFFLLVILWFSRDPETKYVSDATVAIFVATLLFIVPSQKPKFYPP
PLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVP
PAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPC
TLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAV
NTWGRAIFDLDHFPDWAN
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7jsk Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jsk Structure and inhibition mechanism of the human citrate transporter NaCT.
Resolution3.04 Å
Binding residue
(original residue number in PDB)		S136 N141 G220 G226
Binding residue
(residue number reindexed from 1)		S124 N129 G166 G172
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005343 organic acid:sodium symporter activity
GO:0005515 protein binding
GO:0015137 citrate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015142 tricarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006842 tricarboxylic acid transport
GO:0015729 oxaloacetate transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0015744 succinate transport
GO:0015746 citrate transport
GO:0035674 tricarboxylic acid transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
GO:1903825 organic acid transmembrane transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jsk, PDBe:7jsk, PDBj:7jsk
PDBsum7jsk
PubMed33597751
UniProtQ86YT5|S13A5_HUMAN Na(+)/citrate cotransporter (Gene Name=SLC13A5)

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