Structure of PDB 7jkl Chain B Binding Site BS01

Receptor Information
>7jkl Chain B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKVGDGQRIYLVTTYAEF
WFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPANPGADGKKMVALLIE
YVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLIFQLHDVAFKDNIHVG
NFLRKILQPALDLLDLSFLVVKNNMGEKHLFVDLGVYTRNRNFRLYKSSK
IGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLVSNVRFSDTLRILTCE
P
Ligand information
Receptor-Ligand Complex Structure
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PDB7jkl Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Resolution2.384 Å
Binding residue
(original residue number in PDB)		H46 R47 Q48 D73 G74 Q75 R76 Y78 T285 R286
Binding residue
(residue number reindexed from 1)		H10 R11 Q12 D37 G38 Q39 R40 Y42 T188 R189
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jkl, PDBe:7jkl, PDBj:7jkl
PDBsum7jkl
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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