Structure of PDB 7h2f Chain B Binding Site BS01

Receptor Information
>7h2f Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDA1AJ6
InChIInChI=1S/C6H14N2O2S/c1-11(9,10)8-6-2-4-7-5-3-6/h6-8H,2-5H2,1H3
InChIKeyNAEICDPYHCEZMG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=S(C)(=O)NC1CCNCC1
OpenEye OEToolkits 2.0.7CS(=O)(=O)NC1CCNCC1
CACTVS 3.385C[S](=O)(=O)NC1CCNCC1
FormulaC6 H14 N2 O2 S
NameN-(piperidin-4-yl)methanesulfonamide
ChEMBL
DrugBank
ZINC
PDB chain7h2f Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7h2f PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.381 Å
Binding residue
(original residue number in PDB)		D129 Y130 P131 A132 S135 Y150 Y161
Binding residue
(residue number reindexed from 1)		D114 Y115 P116 A117 S120 Y135 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2f, PDBe:7h2f, PDBj:7h2f
PDBsum7h2f
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

[Back to BioLiP]