Structure of PDB 7h2d Chain B Binding Site BS01

Receptor Information
>7h2d Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDGWP
InChIInChI=1S/C7H9N3O/c8-6(11)5-3-9-7(10-5)4-1-2-4/h3-4H,1-2H2,(H2,8,11)(H,9,10)
InChIKeyZIJDZTAYMWKMQH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385NC(=O)c1c[nH]c(n1)C2CC2
OpenEye OEToolkits 2.0.6c1c(nc([nH]1)C2CC2)C(=O)N
FormulaC7 H9 N3 O
Name2-cyclopropyl-1~{H}-imidazole-4-carboxamide
ChEMBL
DrugBank
ZINCZINC000074942043
PDB chain7h2d Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7h2d PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.566 Å
Binding residue
(original residue number in PDB)		Y130 P131 S135 Y161
Binding residue
(residue number reindexed from 1)		Y115 P116 S120 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2d, PDBe:7h2d, PDBj:7h2d
PDBsum7h2d
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

[Back to BioLiP]