Structure of PDB 7h2c Chain B Binding Site BS01

Receptor Information
>7h2c Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDJ4Q
InChIInChI=1S/C8H9N3O2S2/c1-15(12,13)8-9-2-3-11(8)4-7-5-14-6-10-7/h2-3,5-6H,4H2,1H3
InChIKeyDWPGGNJRLYKHCD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385C[S](=O)(=O)c1nccn1Cc2cscn2
OpenEye OEToolkits 2.0.6CS(=O)(=O)c1nccn1Cc2cscn2
FormulaC8 H9 N3 O2 S2
Name4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole
ChEMBL
DrugBank
ZINCZINC000096447797
PDB chain7h2c Chain B Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h2c PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.399 Å
Binding residue
(original residue number in PDB)		Y130 P131 A132 S135 G151 V155 Y161
Binding residue
(residue number reindexed from 1)		Y115 P116 A117 S120 G136 V140 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h2c, PDBe:7h2c, PDBj:7h2c
PDBsum7h2c
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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