Structure of PDB 7h27 Chain B Binding Site BS01

Receptor Information
>7h27 Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDA1AJ1
InChIInChI=1S/C6H9N3O/c1-5(10)9-4-6-7-2-3-8-6/h2-3H,4H2,1H3,(H,7,8)(H,9,10)
InChIKeySXKAQLCLHGQXHB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CC(=O)NCc1[nH]ccn1
ACDLabs 12.01O=C(C)NCc1ncc[NH]1
FormulaC6 H9 N3 O
NameN-[(1H-imidazol-2-yl)methyl]acetamide
ChEMBL
DrugBank
ZINC
PDB chain7h27 Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h27 PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.351 Å
Binding residue
(original residue number in PDB)		Y130 G151 G153 Y161
Binding residue
(residue number reindexed from 1)		Y115 G136 G138 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h27, PDBe:7h27, PDBj:7h27
PDBsum7h27
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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