Structure of PDB 7h1z Chain B Binding Site BS01

Receptor Information
>7h1z Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand IDA1AJU
InChIInChI=1S/C5H6N2/c1-2-5-3-6-4-7-5/h2-4H,1H2,(H,6,7)
InChIKeyMHQZDNQHLGFBRN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		C=Cc1c[nH]cn1
ACDLabs 12.01C=Cc1c[NH]cn1
FormulaC5 H6 N2
Name4-ethenyl-1H-imidazole
ChEMBL
DrugBank
ZINC
PDB chain7h1z Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7h1z PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.38 Å
Binding residue
(original residue number in PDB)		Y130 Y150 Y161
Binding residue
(residue number reindexed from 1)		Y115 Y135 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h1z, PDBe:7h1z, PDBj:7h1z
PDBsum7h1z
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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