Structure of PDB 7h1o Chain B Binding Site BS01

Receptor Information
>7h1o Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKRE
Ligand information
Ligand ID9OI
InChIInChI=1S/C4H6N2O/c5-1-4-2-7-3-6-4/h2-3H,1,5H2
InChIKeyULZXEYFKBUPRQM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385NCc1cocn1
OpenEye OEToolkits 2.0.7c1c(nco1)CN
FormulaC4 H6 N2 O
Name1,3-oxazol-4-ylmethanamine
ChEMBL
DrugBank
ZINCZINC000002527145
PDB chain7h1o Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7h1o PanDDA analysis group deposition of ZIKV NS2B-NS3 protease
Resolution1.41 Å
Binding residue
(original residue number in PDB)		Y130 S135 Y161
Binding residue
(residue number reindexed from 1)		Y115 S120 Y146
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7h1o, PDBe:7h1o, PDBj:7h1o
PDBsum7h1o
PubMed
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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