Structure of PDB 7gnv Chain B Binding Site BS01

Receptor Information
>7gnv Chain B (length=180) Species: 42789 (enterovirus D68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPGFDFAQAIMKKNTVIARTEKGEFTMLGVYDRVAVIPTHASVGEIIYIN
DVETRVLDACALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRCEDDYNDA
VLSVHTSKFPNMYIPVGQVTNYGFLNLGGTPTHRILMYNFPTRAGQCGGV
VTTTGKVIGIHVGGNGAQGFAAMLLHSYFT
Ligand information
Ligand ID60P
InChIInChI=1S/C6H6O2S/c1-4-2-3-9-5(4)6(7)8/h2-3H,1H3,(H,7,8)
InChIKeyIFLKEBSJTZGCJG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.4Cc1ccsc1C(=O)O
CACTVS 3.385Cc1ccsc1C(O)=O
FormulaC6 H6 O2 S
Name3-methylthiophene-2-carboxylic acid
ChEMBLCHEMBL4285249
DrugBank
ZINCZINC000000152287
PDB chain7gnv Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7gnv PanDDA analysis group deposition
Resolution1.42 Å
Binding residue
(original residue number in PDB)		T20 E21 Y48
Binding residue
(residue number reindexed from 1)		T20 E21 Y48
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7gnv, PDBe:7gnv, PDBj:7gnv
PDBsum7gnv
PubMed
UniProtQ68T42|POLG_HED68 Genome polyprotein

[Back to BioLiP]