Structure of PDB 7g98 Chain B Binding Site BS01

Receptor Information
>7g98 Chain B (length=234) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRT
LKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK
ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQ
HSHGIEEERQDLTTALGLVKELLSNVDEGIYQLE
Ligand information
Ligand IDZDL
InChIInChI=1S/C5H12N2/c1-6-3-4-7(2)5-6/h3-5H2,1-2H3
InChIKeySMWUDAKKCDQTPV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CN1CCN(C1)C
ACDLabs 12.01
CACTVS 3.385		CN1CCN(C)C1
FormulaC5 H12 N2
Name1,3-dimethylimidazolidine
ChEMBL
DrugBank
ZINC
PDB chain7g98 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7g98 ARHGEF2 PanDDA analysis group deposition
Resolution2.878 Å
Binding residue
(original residue number in PDB)		C282 E285 T337 E340
Binding residue
(residue number reindexed from 1)		C79 E82 T134 E137
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:7g98, PDBe:7g98, PDBj:7g98
PDBsum7g98
PubMed
UniProtQ92974|ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Gene Name=ARHGEF2)

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