Structure of PDB 7g8q Chain B Binding Site BS01

Receptor Information
>7g8q Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRT
LKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK
ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQ
HSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Ligand information
Ligand IDZ2Z
InChIInChI=1S/C10H9NO2S/c1-14(12,13)9-6-2-4-8-5-3-7-11-10(8)9/h2-7H,1H3
InChIKeyRPUNNHCLJDHINC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01CS(=O)(=O)c1cccc2cccnc12
OpenEye OEToolkits 2.0.7CS(=O)(=O)c1cccc2c1nccc2
CACTVS 3.385C[S](=O)(=O)c1cccc2cccnc12
FormulaC10 H9 N O2 S
Name8-(methanesulfonyl)quinoline
ChEMBL
DrugBank
ZINCZINC000039140297
PDB chain7g8q Chain B Residue 513 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g8q ARHGEF2 PanDDA analysis group deposition
Resolution1.561 Å
Binding residue
(original residue number in PDB)		A220 R311
Binding residue
(residue number reindexed from 1)		A17 R108
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:7g8q, PDBe:7g8q, PDBj:7g8q
PDBsum7g8q
PubMed
UniProtQ92974|ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Gene Name=ARHGEF2)

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