Structure of PDB 7g89 Chain B Binding Site BS01

Receptor Information
>7g89 Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRT
LKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQ
ALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYK
ELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQ
HSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNR
Ligand information
Ligand IDZT7
InChIInChI=1S/C10H10N2O/c1-7(13)12-5-8-2-3-10(11)4-9(8)6-12/h2-6H,11H2,1H3
InChIKeyQUEOWOVPZRUSRH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.385		CC(=O)n1cc2ccc(N)cc2c1
OpenEye OEToolkits 2.0.7CC(=O)n1cc2ccc(cc2c1)N
FormulaC10 H10 N2 O
Name1-(5-amino-2H-isoindol-2-yl)ethan-1-one
ChEMBL
DrugBank
ZINC
PDB chain7g89 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7g89 ARHGEF2 PanDDA analysis group deposition
Resolution1.901 Å
Binding residue
(original residue number in PDB)		L396 R400
Binding residue
(residue number reindexed from 1)		L193 R197
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:7g89, PDBe:7g89, PDBj:7g89
PDBsum7g89
PubMed
UniProtQ92974|ARHG2_HUMAN Rho guanine nucleotide exchange factor 2 (Gene Name=ARHGEF2)

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