Structure of PDB 7f7i Chain B Binding Site BS01
Receptor Information
>7f7i Chain B (length=191) Species:
10116
(Rattus norvegicus) [
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FQGPGSEFVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKRE
YEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ
GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARK
AFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG
Ligand information
>7f7i Chain H (length=12) Species:
32630
(synthetic construct) [
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RIRRDEYLKAIQ
Receptor-Ligand Complex Structure
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PDB
7f7i
Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Resolution
2.595 Å
Binding residue
(original residue number in PDB)
S561 P564 R568 R571 D579 Y580 E600 G602 Y604 Y609 G610 T611
Binding residue
(residue number reindexed from 1)
S39 P42 R46 R49 D57 Y58 E78 G80 Y82 Y87 G88 T89
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7f7i
,
PDBe:7f7i
,
PDBj:7f7i
PDBsum
7f7i
PubMed
34458841
UniProt
P31016
|DLG4_RAT Disks large homolog 4 (Gene Name=Dlg4)
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