Structure of PDB 7ezt Chain B Binding Site BS01

Receptor Information
>7ezt Chain B (length=727) Species: 349741 (Akkermansia muciniphila ATCC BAA-835) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPPVKAGAKQLPMPSVSGAQIKLLGADYEQLVNSKGKIAPVISDTPVNV
SFKVTKDGKEAVSKDYEIMLQAPQAAQGNPKPRIIPEILQWKGGQGEYKL
GNTVTIACPDKELGKLFAADMEDVLGKKVKLVAPGAKADISLSLLKGGNL
GREGYRLQIARDGVRLGAAAPTGLFWGTRTLLQMLRQTPGSVPCGTAVDF
PRYQLRGFMLDVARTPYPLSYLKDVIRTMAWYKMNDLHLVINNNYIFHEH
YVDNGHDPFKESYAAFRLESKMKGKDGTPLTARDLFYTKKEFADLVSYAR
KYGVNIVPEFDTPGHALSFTRLRPDLIYKGPMNHEKRRCEMLDAANPETI
DLVSKVFDEYMLKDPKLGRPVFADCGVVHVGADEFYGDKEDYRHFANAVL
THALKRGYTPRIWGSLSAKPGKTPVVSKGVQMNLWSTGWMKAWEAVNQGY
DVINTNDGALYIVPFAGYYRMDRNHKGLYNNWIPNRIGNETLPSGHPQLL
GGTFAVWNDETDIMHTGYAPYDIWGIISGSMDVLSQKLWGTAKAPDTFEQ
HRELVSSIGNAPRTNPLHKWKDSQPLTVKPSSLPQKLDKPALGPNYRLTM
ELELTAAPEGKEQVLLAAPEGELLAVMKDGTVGFRRDDSLEFSFGAKLPV
GKKVKVEIVGEPEKTSLLLDGEPAGTAVLKNFSDKSKDFSDKFKHRPKVH
RSTFILPLKELGSSFQGKVFHMNVQPL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7ezt Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ezt Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila beta- N -acetylhexosaminidase Am2136.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		Y327 R592
Binding residue
(residue number reindexed from 1)		Y298 R563
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ezt, PDBe:7ezt, PDBj:7ezt
PDBsum7ezt
PubMed36394293
UniProtB2UPR7|H2136_AKKM8 Beta-hexosaminidase Amuc_2136 (Gene Name=Amuc_2136)

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