Structure of PDB 7exe Chain B Binding Site BS01
Receptor Information
>7exe Chain B (length=224) Species:
10090
(Mus musculus) [
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DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNV
VGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLL
EKFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQE
AFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIA
ELDESYKDSTLIMQLLRDNLTLWT
Ligand information
>7exe Chain C (length=12) Species:
10090
(Mus musculus) [
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PRSNSWPRSNST
Receptor-Ligand Complex Structure
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PDB
7exe
LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice
Resolution
2.75 Å
Binding residue
(original residue number in PDB)
R56 R127 Y128 L172 N173 E180 I217 N224
Binding residue
(residue number reindexed from 1)
R55 R126 Y127 L171 N172 E179 I212 N219
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0019901
protein kinase binding
GO:0019904
protein domain specific binding
GO:0031625
ubiquitin protein ligase binding
GO:0042802
identical protein binding
GO:0044325
transmembrane transporter binding
GO:0050815
phosphoserine residue binding
GO:0140297
DNA-binding transcription factor binding
GO:0140311
protein sequestering activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001525
angiogenesis
GO:0003016
respiratory system process
GO:0006468
protein phosphorylation
GO:0006605
protein targeting
GO:0007165
signal transduction
GO:0008039
synaptic target recognition
GO:0030324
lung development
GO:0035148
tube formation
GO:0042149
cellular response to glucose starvation
GO:0043067
regulation of programmed cell death
GO:0045184
establishment of protein localization
GO:0045824
negative regulation of innate immune response
GO:0051683
establishment of Golgi localization
GO:0070371
ERK1 and ERK2 cascade
GO:0070372
regulation of ERK1 and ERK2 cascade
GO:0090128
regulation of synapse maturation
GO:0090168
Golgi reassembly
GO:1900181
negative regulation of protein localization to nucleus
GO:1904262
negative regulation of TORC1 signaling
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005829
cytosol
GO:0042470
melanosome
GO:0098686
hippocampal mossy fiber to CA3 synapse
GO:0098978
glutamatergic synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:7exe
,
PDBe:7exe
,
PDBj:7exe
PDBsum
7exe
PubMed
UniProt
P63101
|1433Z_MOUSE 14-3-3 protein zeta/delta (Gene Name=Ywhaz)
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