Structure of PDB 7eu0 Chain B Binding Site BS01

Receptor Information
>7eu0 Chain B (length=1054) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLSELGEGFLQSFCKKAATSFFDKYGLISHQLNSYNYFIEHGLQNVFQSF
GEMLVEPSWRYATVKFGEVTVEKPTFFSDDKELEFLPWHARLQNMTYSAR
IKVNVQVEVFDILIGSIPVMVKSILCKTSEKGKENCKKGDCAFDQGGYFV
IKGAEKVFIAQEQMCTKRLWISNSPWTVSFRSENKRNRFIVRLSENEKAE
DYKRREKVLTVYFLSTEIPVWLLFFALGVSSDKEAMDLIAFDGDDASITN
SLIASIHVADAVCEAFRCGNNALTYVEQQIKSTKFPPAESVDECLHLYLF
PGLQSLKKKARFLGYMVKCLLNSYAGKRKCENRDSFRNKRIELAGELLER
EIRVHLAHARRKMTRAMQKHLSGKPIEHYLDASVITNGLSRAFSTGAWSH
PFRKMERVSGVVANLGRANPLQTLIDLRRTRQQVDARYPHPSHWGRVCFL
STPDGENCGLVKNMSLLGLVSTQSLESVVEKLFACGMEELMDDTCTPLFG
KHKVLLNGDWVGLCADSESFVAELKSRRRQSELPREMEIKRDKDDNEVRI
FTDAGRLLRPLLVVENLQKLKQEQYPFDHLLDHGILELIGIEEEEDCNTA
WGIKQLLKEPKIYTHCELDLSFLLGVSCAVVPFANHDHGRRVLYQSQKHC
QQAIGFSSTNPNIRCDTLSQQLFYPQKPLFKTLASECLKKEVLFNGQNAI
VAVNVHLGYNQEDSIVMNKASLERGMFRSEQIRSYKAEVDVQFGKTHDSL
EDDGFPFIGANMSTGDIVIGRCHSIKLKHTERGIVQKVVLSSNDEGKNFA
AVSLRQVRSPCLGDKFSSMHGQKGVLGYLEEQQNFPFTIQGIVPDIVINP
HAFPSRQTPGQLLEAALSKGIACPIQAYTKLTRHATPFSTPGVTEITEQL
HRAGFSRWGNERVYNGRSGEMMRSMIFMGPTFYQRLVHMSEDKVKFRNTG
PVHPLTRQPVADRKRFGGIKFGEMERDCLIAHGASANLHERLFTLSDSSQ
MHICRKCKTYANGPYCRVCVSSDHVVRVYVPYGAKLLCQELFSMGITLNF
DTKL
Ligand information
>7eu0 Chain O (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgagagguacuuuucuuuucuuucuucuucgg
................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7eu0 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		R713 R714 K721 Q725 K921 S953 H1042
Binding residue
(residue number reindexed from 1)		R640 R641 K648 Q652 K823 S855 H938
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0050776 regulation of immune response
GO:0050832 defense response to fungus
GO:0080188 gene silencing by siRNA-directed DNA methylation
GO:0141007 siRNA-mediated retrotransposon silencing by heterochromatin formation
Cellular Component
GO:0000418 RNA polymerase IV complex
GO:0000419 RNA polymerase V complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0030880 RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7eu0, PDBe:7eu0, PDBj:7eu0
PDBsum7eu0
PubMed34941388
UniProtQ9LK40|NRPD2_ARATH DNA-directed RNA polymerases IV and V subunit 2 (Gene Name=NRPD2)

[Back to BioLiP]