Structure of PDB 7egd Chain B Binding Site BS01

Receptor Information
>7egd Chain B (length=963) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSK
QCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVD
PDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEG
SMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNG
DLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHF
CLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAA
YASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEW
VLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIF
NPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNK
LLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQ
SGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSF
NHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPL
LWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTP
ASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTR
MFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFI
LDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPD
VRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFK
SYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHK
ILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY
FTLFGLSRPSCLP
Ligand information
>7egd Chain X (length=72) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctataaaagggggtgggggcgcgttcgtcctcagtcgcgatcgaacactc
gagccgagcagacgtgcctacg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7egd Structural insights into preinitiation complex assembly on core promoters.
Resolution6.75 Å
Binding residue
(original residue number in PDB)		K540 R541
Binding residue
(residue number reindexed from 1)		K515 R516
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006282 regulation of DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0014070 response to organic cyclic compound
GO:0042789 mRNA transcription by RNA polymerase II
GO:0045893 positive regulation of DNA-templated transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0033276 transcription factor TFTC complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7egd, PDBe:7egd, PDBj:7egd
PDBsum7egd
PubMed33795473
UniProtQ6P1X5|TAF2_HUMAN Transcription initiation factor TFIID subunit 2 (Gene Name=TAF2)

[Back to BioLiP]