Structure of PDB 7e9h Chain B Binding Site BS01

Receptor Information
>7e9h Chain B (length=306) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS
YTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVR
VSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHT
GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICF
FPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRL
LLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
FLKIWN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7e9h Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		Y85 S281 N340
Binding residue
(residue number reindexed from 1)		Y51 S247 N306
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0030159 signaling receptor complex adaptor activity
GO:0044877 protein-containing complex binding
GO:0051020 GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0008283 cell population proliferation
GO:0050909 sensory perception of taste
GO:0060041 retina development in camera-type eye
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071870 cellular response to catecholamine stimulus
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0097381 photoreceptor disc membrane
GO:1903561 extracellular vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e9h, PDBe:7e9h, PDBj:7e9h
PDBsum7e9h
PubMed34135510
UniProtP62873|GBB1_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Gene Name=GNB1)

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